2BAct( eIF2B activator 2BAct )

Catalog No. M13427 CAS No. 2143542-28-1

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Product Name

2BAct
Note

Research use only, not for human use.
Brief Description

2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays.
Description

2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays; 2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice; also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice.
In Vitro

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In Vivo

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Synonyms

eIF2B activator 2BAct
Pathway

Nuclear Receptor/Transcription Factor
Target

eIF
Recptor

eIF
Research Area

——
Indication

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CAS Number

2143542-28-1
Formula Weight

440.807
Molecular Formula

C19H16ClF3N4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (567.15 mM)
SMILES

O=C(C1=NC=C(C(F)F)N=C1)NC2(C3)CC3(NC(COC4=CC=C(Cl)C(F)=C4)=O)C2
Chemical Name

N-(3-(2-(4-chloro-3-fluorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-5-(difluoromethyl)pyrazine-2-carboxamide

1. Wong YL, et al. Elife. 2019 Jan 9;8. pii: e42940. doi: 10.7554/eLife.42940.

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