2,2,2-Trichloroethanol( —— )

Catalog No. M28141 CAS No. 115-20-8

2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

2,2,2-Trichloroethanol
Note

Research use only, not for human use.
Brief Description

2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.
Description

2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.(In Vitro):2,2,2-trichloroethanol dilated the middle cerebral artery and activated the potassium channel in cerebrovascular smooth muscle.
In Vitro

2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery.
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

5-HT4
Research Area

——
Indication

——

Chemical Information

CAS Number

115-20-8
Formula Weight

149.4
Molecular Formula

C2H3Cl3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (669.34 mM)
SMILES

OCC(Cl)(Cl)Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700.

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