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1V209
CAS No. 1062444-54-5
1V209( TLR7 agonist T7 )
Catalog No. M21560 CAS No. 1062444-54-5
1V209 ?is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | Get Quote |
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| 5MG | 65 | Get Quote |
|
| 10MG | 115 | Get Quote |
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| 25MG | 258 | Get Quote |
|
| 50MG | 410 | Get Quote |
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| 100MG | 605 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name1V209
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NoteResearch use only, not for human use.
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Brief Description1V209 ?is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
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Description1V209 ?is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
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In Vitro1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells. 1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells.
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In VivoThe intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration.
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SynonymsTLR7 agonist T7
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR7
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Research Area——
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Indication——
Chemical Information
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CAS Number1062444-54-5
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Formula Weight359.34
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Molecular FormulaC16H17N5O5
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (231.90 mM; Need ultrasonic)
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SMILESCOCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(cc3)C(O)=O)c2n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α?Mannose as Adjuvants[J]. Bioconjugate Chemistry 2019 30(11):2811-2821.
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