12(S)-HETE( —— )

Catalog No. M34904 CAS No. 54397-83-0

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1μM181M.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

12(S)-HETE
Note

Research use only, not for human use.
Brief Description

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1μM181M.
Description

12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

54397-83-0
Formula Weight

320.47
Molecular Formula

C20H32O3
Purity

>98% (HPLC)
Solubility

——
SMILES

C(\[C@H](C/C=C\CCCCC)O)=C/C=C\C/C=C\CCCC(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ding XZ, et al. 12-lipoxygenase metabolite 12(S)-HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int J Cancer. 2001 Dec 1;94(5):630-6.?

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