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0990CL
CAS No. 511514-03-7
0990CL( —— )
Catalog No. M33243 CAS No. 511514-03-7
0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 324 | Get Quote |
|
| 5MG | 511 | Get Quote |
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| 10MG | 739 | Get Quote |
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| 25MG | 1086 | Get Quote |
|
| 50MG | 1490 | Get Quote |
|
| 100MG | 1962 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product Name0990CL
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NoteResearch use only, not for human use.
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Brief Description0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation.
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Description0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi. 0990CL is able to block α2AR mediated regulation of cAMP.
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In Vitro0990CL?(100 nM-1 μM; 24 hours) is able to restore α2AR/Gαi?mediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL?(30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαi?and Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetcAMP
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RecptorcAMP
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Research Area——
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Indication——
Chemical Information
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CAS Number511514-03-7
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Formula Weight343.42
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Molecular FormulaC21H21N5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (727.97 mM; Ultrasonic )
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SMILESN(C=1N=C(C2=C(N1)C=CC=C2)C3=CC=CC=C3)C=4NC(C)(C)C=C(C)N4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Appleton KM,et al. Development of inhibitors of heterotrimeric Gαi subunits.Bioorg Med Chem. 2014 Jul 1;22(13):3423-34.?
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