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(R)-9bMS
CAS No. ——
(R)-9bMS( R)-9b methanesulfonate )
Catalog No. M16923 CAS No. ——
(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name(R)-9bMS
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NoteResearch use only, not for human use.
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Brief Description(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM.
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Description(R)-9bMS is a potent and selective ACK1 (TNK2) inhibitor with IC50 of 48 nM; also inhibits JAK2 (IC50=6 nM) and Tyk2 (IC50=5 nM), 3-fold selectvity over ALK and 10-fold over c-Src; potently suppresses proliferation of human cancer cell lines with IC50 <2 uM; exhibits considerable stability in human plasma and a long half-life.
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In Vitro——
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In Vivo——
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SynonymsR)-9b methanesulfonate
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PathwayTyrosine Kinase
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TargetAck1 (TNK2)
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RecptorAck1 (TNK2)
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight499.027
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Molecular FormulaC21H31ClN6O4S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-5-chloro-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N4-((tetrahydrofuran-2-yl)methyl)pyrimidine-2,4-diamine methanesulfonate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mahajan K, et al. Cancer Cell. 2017 Jun 12;31(6):790-803.e8.
2. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983.
3. Lawrence HR, et al. J Med Chem. 2015 Mar 26;58(6):2746-63.
molnova catalog
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(R)-9bMS
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