SMO-IN-2

SMO-IN-2

Catalog No. M35720

SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.

Size Price / USD Stock Quantity
5MG 252 In Stock
10MG 378 In Stock
25MG 618 In Stock
50MG 814 In Stock
100MG 1088 In Stock
200MG 1469 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SMO-IN-2
  • Brief Description
  • Description
  • Storage
  • Note
    Research use only, not for human use.
  • Reference
    1. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.?
molnova catalog
related products
  • Cucurbitacin B

    Cucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN.

  • Robotnikinin

    Robotnikinin is asmall molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines.

  • Purmorphamine

    Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.