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Tecalcet

CAS No. 148717-54-8

Tecalcet( R-568 | NPS R-568 | KRN-568 | NPS-568 )

Catalog No. M12052 CAS No. 148717-54-8

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Tecalcet
  • Note
    Research use only, not for human use.
  • Brief Description
    Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
  • Description
    Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR; potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion (IC50=27 nM in bovine parathyroid cells) without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs. Hyperparathyroidism Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    R-568 | NPS R-568 | KRN-568 | NPS-568
  • Pathway
    GPCR/G Protein
  • Target
    CaSR
  • Recptor
    CaSR
  • Research Area
    Endocrinology
  • Indication
    Hyperparathyroidism

Chemical Information

  • CAS Number
    148717-54-8
  • Formula Weight
    303.83
  • Molecular Formula
    C18H22ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C1=CC(=CC=C1)OC)NCCCC2=CC=CC=C2Cl
  • Chemical Name
    2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wada MJ Clin Invest. 1997 Dec 15;100(12):2977-83., et al. 2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5. 3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8. 4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.
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