TP-10( —— )

Catalog No. M26489 CAS No. 898563-00-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

TP-10
Note

Research use only, not for human use.
Brief Description

TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
Description

TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.(In Vivo):TP-10 is active in the mouse behavioral model for positive symptoms. TP-10 demonstrates good in vitro and in vivo activity with extremely high intrinsic clearance (CLint) of t>1000 mL/min/kg in mouse liver microsomes (MLM) in assay.
In Vitro

TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG). Cell Viability Assay Cell Line:U-87 MG cells Concentration:10 μg/ml Incubation Time:24 hours Result:Decreased the total number of ROS-positive cells and showed no toxic effects to U-87 MG cells.
In Vivo

TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides. Animal Model:Male CD ratsDosage:0.1, 0.32, 1.0, 3.2 and 10 mg/kg Administration:Subcutaneous injection; 0.1-10 mg/kg once Result:Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.
Synonyms

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Pathway

Angiogenesis
Target

PDE
Recptor

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Research Area

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Indication

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1.Tadros W, Boulos AL. Selective hydrogenation of ergosterol and its acetate. Helv Chim Acta. 1975 Apr 23;58(3):668-71.

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