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TNP-470
CAS No. 129298-91-5
TNP-470( TNP470 | AGM-1470 | AGM1470 )
Catalog No. M11185 CAS No. 129298-91-5
TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 590 | Get Quote |
|
| 50MG | 2475 | Get Quote |
|
| 100MG | 3753 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTNP-470
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NoteResearch use only, not for human use.
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Brief DescriptionTNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound.
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DescriptionTNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis; has anti-growth factor properties and inhibits the activation of Cdk 2 and phosphorylation of RB protein, inhibits potently PDGF- and bFGF-stimulated proliferation of rat mesangial cells in vitro (IC50 = 50 pg/ml); inhibits tumor growth and metastasis of rodent tumors; does not bind to or inhibit MetAP-1.Blood CancerPhase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTNP470 | AGM-1470 | AGM1470
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PathwayMetabolic Enzyme/Protease
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TargetAminopeptidase
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RecptorAminopeptidase
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number129298-91-5
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Formula Weight401.884
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Molecular FormulaC19H28ClNO6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (248.83 mM)
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SMILESO=C(NC(CCl)=O)O[C@@H]1CC[C@@]2(OC2)[C@]([C@](O3)(C)[C@H]3C/C=C(C)/C)([H])[C@@H]1OC
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Chemical NameCarbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yamaoka M, et al. Cancer Res. 1993 Sep 15;53(18):4262-7.
2. Haraguchi M, et al. Kidney Int. 1997 Jun;51(6):1838-46.
3. Garrabrant T, et al. Angiogenesis. 2004;7(2):91-6.
4. Ingber D, et al. Nature. 1990 Dec 6;348(6301):555-7.
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