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TFAP

CAS No. 1011244-68-0

TFAP( TFAP )

Catalog No. M19375 CAS No. 1011244-68-0

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	102	In Stock
25MG	196	In Stock
50MG	356	In Stock
100MG	530	In Stock
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Biological Information

Product Name

TFAP
Note

Research use only, not for human use.
Brief Description

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor.
Description

TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor by targeting the enzyme's active site. TFAP displays analgesic properties in mice and rats in vivo without long-term cytotoxic effects. Unlike COX-2-inhibiting analgesics such as aspirin, TFAP is shown not to cause gastric damage in rats in vivo.
In Vitro

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM, while that against COX-2 is over 200 μM.
In Vivo

——
Synonyms

TFAP
Pathway

Chromatin/Epigenetic
Target

COX
Recptor

COX-1
Research Area

——
Indication

——

Chemical Information

CAS Number

1011244-68-0
Formula Weight

281.23
Molecular Formula

C13H10F3N3O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 155 mg/mL; 551.15 mM
SMILES

O=C(Nc1ccc(N)cn1)c2ccc(cc2)C(F)(F)F
Chemical Name

N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)-benzamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kakuta H, et al. Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1840-3.

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