Seselin

Research use only, not for human use.

Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity.

Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity.(In Vitro):Seselin (10uM) blocked signalling pathways that mediate the classical activation of macrophages in bone marrow‐derived macrophages.(In Vivo):Seselin (3mg/kg, 10mg/kg, 30mg/kg, iv) ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during mouse sepsis.

RT-PCRCell Line:Bone marrow-derived macrophages (BMDMs)Concentration:5, 10 and 20 μM Incubation Time:6 h Result:Reduced the mRNA for cytokines (IL-1β, IL-6, Tnf-α and IL-23) and chemokines (Ccl3, Ccl7, Cxcl9 and Cxcl11) concentration-dependently in BMDMs.Western Blot Analysis Cell Line:BMDMs Concentration:5, 10 and 20 μM Incubation Time:0.5, 1.5, 3 and 6 h Result:Suppressed expression of p-STAT1 and p-p65 both concentration and time dependently.

Animal Model:Male Swiss miceDosage:0.5, 4.5 or 40.5 mg/kg Administration:Subcutaneous injection; onceResult:Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.Animal Model:C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model Dosage:3, 10 and 30 mg/kg Administration:Intragastric administration, once Result:Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.

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Immunology/Inflammation

Antiviral

Antiviral

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523-59-1

228.247

C14H12O3

>98% (HPLC)

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CC1(C)Oc2ccc3ccc(=O)oc3c2C=C1

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(-20℃)

With Ice Pack

≥ 2 years