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Raptinal
CAS No. 1176-09-6
Raptinal( —— )
Catalog No. M35049 CAS No. 1176-09-6
Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 109 | In Stock |
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| 25MG | 174 | In Stock |
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| 50MG | 257 | In Stock |
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| 100MG | 372 | In Stock |
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| 200MG | 554 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRaptinal
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NoteResearch use only, not for human use.
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Brief DescriptionRaptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
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DescriptionRaptinal, a agent that directly activates caspase-3, initiates intrinsic pathway caspase-dependent apoptosis. Raptinal is able to rapidly induce cancer cell death by directly activating the effector caspase-3, bypassing the activation of initiator caspase-8 and caspase-9.
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In VitroCell Viability Assay Cell Line:Human Lymphoma U-937, SKW 6.4, or Jurkat cell lines Concentration:0.7-3.4 μM Incubation Time:24 hours Result:The IC50?values of Raptinal against U-937, SKW 6.4, or Jurkat cell lines were 1.1±0.1, 0.7±0.3, 2.7±0.9 μM, respectively.Western Blot Analysis Cell Line:Human gastric cancer cell lines AGS, MKN28, MKN45 Concentration:10?μM Incubation Time:2 hours Result:Induced apoptosis by activating caspase-3 within 30?min at a concentration of 10?μM. Treatment with 10?μM of Raptinal for 2?h induced the cleavage of pro-caspase-3 into it’s active form in all three cell lines.?
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In VivoAnimal Model:C57BL/6 and BALB/c female mice (6-8 weeks old) bearing the B16-F10 model or 4T1 modelsDosage:20 mg/kg Administration:Administered intraperitoneally; once daily for 3 consecutive days for B16-F10 and 4 consecutive days for 4T1 models Result:Retard tumor volume and tumor mass by 60% relative to controls in the B16-F10 model.Similar efficacy was observed for the 4T1 murine breast cancer tumor model with 50% growth inhibition after treatment.?
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Synonyms——
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase
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Research Area——
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Indication——
Chemical Information
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CAS Number1176-09-6
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Formula Weight386.44
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Molecular FormulaC28H18O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (51.75 mM; Ultrasonic (<60°C)
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SMILESO=CC1(c2ccccc2-c2ccccc12)C1(C=O)c2ccccc2-c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yanheng Chen,?et al. H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis. Cell Death Dis.?2020 Aug 21;11(8):667.?
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