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RUSKI-201
CAS No. 1458031-48-5
RUSKI-201( RUSKI 201 | RUSKI201 )
Catalog No. M11977 CAS No. 1458031-48-5
A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRUSKI-201
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
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DescriptionA potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.
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In Vitro——
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In Vivo——
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SynonymsRUSKI 201 | RUSKI201
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorHedgehog (Hh)
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Research Area——
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Indication——
Chemical Information
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CAS Number1458031-48-5
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Formula Weight357.516
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Molecular FormulaC20H27N3OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC=CC(C2C(C=CS3)=C3CCN2C(CNCC(C)CC)=O)=N1
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Chemical Name1-[6,7-Dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]ethanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.
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