Phloracetophenone( —— )

Catalog No. M18613 CAS No. 480-66-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Phloracetophenone
Note

Research use only, not for human use.
Brief Description

2', 4', 6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
Description

2', 4', 6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
In Vitro

Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level.Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver.
In Vivo

Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis.
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

MMP
Recptor

Others
Research Area

Others-Field
Indication

——

1. Lai YH, et al. Rapid Commun Mass Spectrom. 2014 Aug 15;28(15):1716-22.

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