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PHA-680632
CAS No. 398493-79-3
PHA-680632( PHA680632 | PHA 680632 )
Catalog No. M14369 CAS No. 398493-79-3
A potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | Get Quote |
|
| 10MG | 65 | Get Quote |
|
| 25MG | 132 | Get Quote |
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| 50MG | 230 | Get Quote |
|
| 100MG | 384 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePHA-680632
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.
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DescriptionA potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively; exhibits at least 30- to 200-fold selectivity against a panel of 22 kinases compared with Aurora A; has potent antiproliferative activity in a wide range of cancer cell types (IC50=0.06-7.15 uM); shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.
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In Vitro——
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In Vivo——
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SynonymsPHA680632 | PHA 680632
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAurora A| Aurora B| Aurora C| FGFR1| PLK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number398493-79-3
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Formula Weight501.6232
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Molecular FormulaC28H35N7O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO=C(N(C1)CC2=C1C(NC(C3=CC=C(N4CCN(C)CC4)C=C3)=O)=NN2)NC5=C(CC)C=CC=C5CC
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Chemical NamePyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Soncini C, et al. Clin Cancer Res. 2006 Jul 1;12(13):4080-9.
2. Tao Y, et al. Br J Cancer. 2007 Dec 17;97(12):1664-72.
3. Ratushny V, et al. Oncogene. 2012 Mar 8;31(10):1217-27.
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SCH-1473759
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