PF-05387252( PF 05387252 | PF05387252 )

Catalog No. M12301 CAS No. 1604034-71-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-05387252
Note

Research use only, not for human use.
Brief Description

A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
Description

A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM); exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=18 nM) in human PBMCs; inhibits LPS-induced TNFα in an in vivo murine model.
In Vitro

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In Vivo

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Synonyms

PF 05387252 | PF05387252
Pathway

Immunology/Inflammation
Target

IRAK
Recptor

IRAK
Research Area

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Indication

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CAS Number

1604034-71-0
Formula Weight

429.524
Molecular Formula

C25H27N5O2
Purity

>98% (HPLC)
Solubility

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SMILES

N#CC1=CC(N2)=C(C3=C2C4=CC(OC)=C(OCCCN5CCN(C)CC5)C=C4N=C3)C=C1
Chemical Name

11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]-

1. Lai CY, et al. J Immunol Res. 2017;2017:7807313. 2. Tumey LN, et al. Bioorg Med Chem Lett. 2014 May 1;24(9):2066-72.

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