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Oxyphenbutazone

CAS No. 129-20-4

Oxyphenbutazone( —— )

Catalog No. M33449 CAS No. 129-20-4

Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Oxyphenbutazone
  • Note
    Research use only, not for human use.
  • Brief Description
    Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative.
  • Description
    Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
  • In Vitro
    Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells.Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells.Oxyphenbutazone exhibits reparative effects in the hepatocytes.Cell Cytotoxicity Assay Cell Line:Hep3B cells Concentration:2.5 μM, 5 μM, 7.5 μM Incubation Time:48 hours Result:Enhanced the cytotoxicity of MTX.
  • In Vivo
    Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).Animal Model:Wistar strain albino male rats (5-6 weeks; 150-220 g) Dosage:70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) Administration:PO; once a week; in two divided doses; for 13 weeks Result:Exerted potential anticancer activity in rats when co-treatment with MTX.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    129-20-4
  • Formula Weight
    324.37
  • Molecular Formula
    C19H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (308.29 mM; Ultrasonic )
  • SMILES
    CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196.?
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