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Home - Products - Angiogenesis - HIF/HIF Prolyl-hydroxylase - OHM1

OHM1

CAS No. 1450995-09-1

OHM1( OHM 1 )

Catalog No. M11943 CAS No. 1450995-09-1

OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    OHM1
  • Note
    Research use only, not for human use.
  • Brief Description
    OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM.
  • Description
    OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals.
  • In Vitro
    RT-PCR Cell Line:A549 Concentration:10 μM Incubation Time:24 h Result:Down-regulated the mRNA expression levels of the critical angiogenesis regulator vascular endothelial growth factor (VEGFA) by 80%. Decreased lysyl oxidase (LOX) and glucose transporter 1 (GLUT1) expression.
  • In Vivo
    Animal Model:BALB/c mice, MDA-MB-231 xenograft model Dosage:15 mg/kg Administration:Intraperitoneal injection, every other day for 15 injections Result:Reduced the median tumor volume by roughly 50% compared with the untreated group. Did not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals, nor increased the metastasis rate.
  • Synonyms
    OHM 1
  • Pathway
    Angiogenesis
  • Target
    HIF/HIF Prolyl-hydroxylase
  • Recptor
    HIF/HIF Prolyl-hydroxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1450995-09-1
  • Formula Weight
    494.637
  • Molecular Formula
    C24H42N6O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (S)-2-((S)-4-((S)-2-((S)-3-isobutyl-2-oxopiperazin-1-yl)-4-methylpentanoyl)-3-methyl-2-oxopiperazin-1-yl)pentanediamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6. 3. Fang Y, et al. Exp Cell Res. 2007 Mar 10;313(5):867-77.
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