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MMPSI

CAS No. 220509-74-0

MMPSI( —— )

Catalog No. M33769 CAS No. 220509-74-0

MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 149 Get Quote
5MG 312 Get Quote
10MG 502 Get Quote
25MG 907 Get Quote
50MG 1435 Get Quote
100MG 2178 Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    MMPSI
  • Note
    Research use only, not for human use.
  • Brief Description
    MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.
  • Description
    MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase | Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    220509-74-0
  • Formula Weight
    324.35
  • Molecular Formula
    C14H16N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (308.31 mM; Ultrasonic )
  • SMILES
    O=C1C=2C(=CC=C(S(=O)(=O)N3[C@H](COC)CCC3)C2)NC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59-68.?
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