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MK-8617
CAS No. 1187990-87-9
MK-8617( MK 8617 | MK8617 )
Catalog No. M10644 CAS No. 1187990-87-9
A potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 80 | In Stock |
|
| 25MG | 155 | In Stock |
|
| 50MG | 294 | In Stock |
|
| 100MG | 437 | In Stock |
|
| 200MG | 624 | In Stock |
|
| 500MG | 981 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMK-8617
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively.
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DescriptionA potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively; shows no significant inhibition on the cytochrome p450 enzymes; exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.
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In Vitro——
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In Vivo——
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SynonymsMK 8617 | MK8617
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorPHD1|PHD2|PHD3|PHD1,PHD2,PHD3
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1187990-87-9
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Formula Weight443.45
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Molecular FormulaC24H21N5O4
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Purity>98% (HPLC)
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SolubilityDMSO: 16 mg/mL (36.1 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESCOC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4
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Chemical NameN-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Debenham JS, et al. J Med Chem. 2016 Dec 22;59(24):11039-11049.
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