TRAP-14

Research use only, not for human use.

TRAP-14 (SFLLRNPNDKYEPF) is a synthetic thrombin receptor agonist peptide.

Sfllrnpndkyepf is a synthetic thrombin receptor agonist peptide.

Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence TRAP-14. This peptide (TRAP-14) may signal a variety of thrombin's responses. TRAP-14, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. TRAP-14, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. TRAP-14 is the minimal peptide length which retains full activity in inducing [14C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin.

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Others

Other Targets

Others

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137339-65-2

1739.96

C81H118N20O23

>98% (HPLC)

H2O : ≥ 100 mg/mL (57.47 mM)

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(-20℃)

With Ice Pack

≥ 2 years