YAP-TEAD-IN-3( —— )

Catalog No. M37083 CAS No. 2714434-21-4

YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

YAP-TEAD-IN-3
Note

Research use only, not for human use.
Brief Description

YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434).
Description

YAP-TEAD-IN-3 (compound 155) is a YAP/TAZ-TEAD inhibitor. YAP-TEAD-IN-3 inhibits Avi-humanTEAD4217-434 with an IC50 value of 9 nM. YAP-TEAD-IN-3 also inhibits NCI-H2052 with an GI50of 0.048 μM (cell proliferation)，and an IC50 of 0.048 μM (YAP reporter gene expression)，respsectively.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

YAP
Research Area

——
Indication

——

Chemical Information

CAS Number

2714434-21-4
Formula Weight

529.96
Molecular Formula

C27H26ClF2N3O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (235.87 mM; Ultrasonic )
SMILES

O=C(NC)C1=CN=C(OCCO)C(F)=C1C=2C(Cl)=C(F)C=C3OC(C=4C=CC=CC4)(CC32)C5NCCC5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.

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