Ampreloxetine hydrochloride

Research use only, not for human use.

Ampreloxetine hydrochloride (TD-9855 HCl) has anti-inflammatory activity and is a potential compound for the treatment of depression and Alzheimer's disease.

Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma.

——

Animal Model:RatDosage:0.3, 1, 5, 10, 30, and 60mg/kg Administration:PO; euthanized by decapitation at 0.5, 2, 4, 6, and 8 hr for 5mg/ kg dose level; 2 hr for 0.3, 1, 10, 30, and 60mg/kg dose levels Result:In the effect compartment PK/PD analysis for NET and SERT occupancy, the estimated EC50 for occupancy was 11.7ng/mL for NET and 50.8ng/mL for SERT in rat spinal cords, and the projected human plasma EC50 values were 5.5ng/mL for NET and 23.9ng/mL for SERT.

——

Others

Other Targets

Others

——

——

1227056-87-2

357.8

C18H19ClF3NO

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (279.49 mM; Ultrasonic )

Cl.FC=1C=C(F)C(OCC=2C=CC=CC2C3CCNCC3)=C(F)C1

——

(-20℃)

With Ice Pack

≥ 2 years