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MRK-740

CAS No. 2387510-80-5

MRK-740( —— )

Catalog No. M35683 CAS No. 2387510-80-5

MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 112 In Stock
5MG 100 In Stock
10MG 163 In Stock
25MG 353 In Stock
50MG 555 In Stock
100MG 817 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    MRK-740
  • Note
    Research use only, not for human use.
  • Brief Description
    MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation.
  • Description
    MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histone Methyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2387510-80-5
  • Formula Weight
    464.56
  • Molecular Formula
    C25H32N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 40 mg/mL (86.10 mM)
  • SMILES
    COc1cc(OC)cc(c1)-c1noc(n1)N1CCN(C)C2(CCN(CC2)c2ccnc(C)c2)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Abdellah Allali-Hassani, et al. Discovery of a Chemical Probe for PRDM9. Nat Commun. 2019 Dec 17;10(1):5759.?
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