Cart
sales@molnova.com
MRK-740
CAS No. 2387510-80-5
MRK-740( —— )
Catalog No. M35683 CAS No. 2387510-80-5
MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 100 | Get Quote |
|
| 10MG | 163 | Get Quote |
|
| 25MG | 342 | Get Quote |
|
| 50MG | 549 | Get Quote |
|
| 100MG | 791 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMRK-740
-
NoteResearch use only, not for human use.
-
Brief DescriptionMRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation.
-
DescriptionMRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 μM).
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHistone Methyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2387510-80-5
-
Formula Weight464.56
-
Molecular FormulaC25H32N6O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 40 mg/mL (86.10 mM)
-
SMILESCOc1cc(OC)cc(c1)-c1noc(n1)N1CCN(C)C2(CCN(CC2)c2ccnc(C)c2)C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Abdellah Allali-Hassani, et al. Discovery of a Chemical Probe for PRDM9. Nat Commun. 2019 Dec 17;10(1):5759.?
molnova catalog
related products
-
Lecirelin
Lecirelin is a synthetic GnRH (gonadotropin releasing hormone) analogue which shows a great efficacy in the treatment of bovine ovarian follicular cysts.
-
Sanggenol L
Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemotherapeutic agent for ovarian cancers.
-
WAY-600
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM.
