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9-cis-Retinoic Acid
CAS No. 5300-03-8
9-cis-Retinoic Acid( —— )
Catalog No. M33736 CAS No. 5300-03-8
9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 117 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 364 | In Stock |
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| 50MG | 569 | In Stock |
|
| 100MG | 894 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name9-cis-Retinoic Acid
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NoteResearch use only, not for human use.
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Brief Description9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors.
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Description9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and hasanticancer, anti-inflammatory and neuroprotection activities.
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In VitroCell Proliferation Assay Cell Line:CA 9-22 and NA cells Concentration:1 μM, 10 μM Incubation Time:0 day, 1 day, 3 days, 5 days Result:Significantly decreased proliferation.
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In VivoAnimal Model:Male C57BL/6J mice (6-8 weeks; 19-22 g) treatment with bile duct ligated Dosage:1 mg/kg Administration:Intravenous injection; daily; for 10 days Result:Significantly decreased the serum ALT and AST level, alleviated hepatic necrosis.
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number5300-03-8
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Formula Weight300.44
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Molecular FormulaC20H28O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (83.21 mM; Ultrasonic )
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SMILESC\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080.?
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