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MRE3008F20
CAS No. 252979-43-4
MRE3008F20( —— )
Catalog No. M33435 CAS No. 252979-43-4
MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.CAS 13483-88-88-9
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 97 | Get Quote |
|
| 5MG | 147 | Get Quote |
|
| 10MG | 217 | Get Quote |
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| 25MG | 357 | Get Quote |
|
| 50MG | 523 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMRE3008F20
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NoteResearch use only, not for human use.
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Brief DescriptionMRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.CAS 13483-88-88-9
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DescriptionMRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R.
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In VitroMRE3008F20 (0.1-100 nM) antagonizes 100 nM Cl-IB-MECA-induced inhibition of cAMP levels in resting human lymphocytes.Cell Viability Assay Cell Line:Human lymphocytes Concentration:0.1-100 nM Incubation Time: Result:Antagonized 100 nM Cl-IB-MECA-induced inhibition of cAMP levels with an IC50 of 5.0 nM in resting Lymphocytes.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetAdenosine Receptor
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RecptorAdenosine Receptor | cAMP
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Research Area——
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Indication——
Chemical Information
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CAS Number252979-43-4
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Formula Weight432.44
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Molecular FormulaC21H20N8O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=C(OC)C=C1)NC2=NC3=NN(C=C3C4=NC(=NN24)C=5OC=CC5)CCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gessi S, et al. Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation. Mol Pharmacol. 2004 Mar;65(3):711-9.?
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