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PHYTOSPHINGOSINE

CAS No. 554-62-1

PHYTOSPHINGOSINE( —— )

Catalog No. M28720 CAS No. 554-62-1

Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
25MG 38 In Stock
50MG 48 In Stock
100MG 68 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PHYTOSPHINGOSINE
  • Note
    Research use only, not for human use.
  • Brief Description
    Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.
  • Description
    Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.
  • In Vitro
    Cell Viability Assay Cell Line:A549, LLC, BEAS-2B Concentration:1 μg/mL, 2 μg/mL, 3 μg/mL, 4 μg/mL, 5 μg/mL Incubation Time:24 h, 48 h Result:Significantly inhibited cell proliferation in a concentration- and time-dependent manner.Cell Cycle Analysis Cell Line:A549 Concentration:1 μg/mL, 3 μg/mL, 5 μg/mL Incubation Time:24 h Result:Significantly increased the proportion of G2/M phase cells.Western Blot Analysis Cell Line:A549 Concentration:1 μg/mL, 3 μg/mL, 5 μg/mL Incubation Time:24 hResult:Up-regulated the pro-apoptotic factor Bax protein level and down-regulated the anti-apoptotic factor Bcl-2 protein level.Promoted the release of cytochrome c to up-regulate caspase 9 and caspase 3 levels, leading to PARP cleavage.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    PDGFR|FGFR|Src|p38|TNF-α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    554-62-1
  • Formula Weight
    317.514
  • Molecular Formula
    C18H39NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (157.48 mM)
  • SMILES
    CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3(12):1181-93.
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