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Lalistat 1

CAS No. 501104-16-1

Lalistat 1( ZINC795230 )

Catalog No. M28175 CAS No. 501104-16-1

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lalistat 1
  • Note
    Research use only, not for human use.
  • Brief Description
    Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae.
  • Description
    Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.(In Vitro):Lalistat 1 (0-100 μM) dose-dependently inhibits IgA1P B1 and B2, almost completely at 50 μM and completely at 100 μM .Lalistat 1 reduces cholesterol accumulation in lysosome-like reservoirs of GM03123 human fibroblasts lacking NPC1 .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ZINC795230
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    MMP-12
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    501104-16-1
  • Formula Weight
    298.36
  • Molecular Formula
    C12H18N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (67.03 mM)
  • SMILES
    O=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76.
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