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Rotigotine (b)
CAS No. 92206-54-7
Rotigotine (b)( 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- )
Catalog No. M24970 CAS No. 92206-54-7
Rotigotine is an antiparkinson agent and dopamine receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 36 | In Stock |
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| 25MG | 60 | In Stock |
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| 50MG | 85 | In Stock |
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| 100MG | 127 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRotigotine (b)
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NoteResearch use only, not for human use.
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Brief DescriptionRotigotine is an antiparkinson agent and dopamine receptor agonist.
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DescriptionRotigotine is an antiparkinson agent and dopamine receptor agonist.
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In VitroRotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7).Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
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In Vivo——
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Synonyms1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine
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Research Area——
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Indication——
Chemical Information
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CAS Number92206-54-7
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Formula Weight315.47
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Molecular FormulaC19H25NOS
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCN(CCc1cccs1)C(CC1)Cc2c1c(O)ccc2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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ONC206
ONC206 is an analogue of TRAIL inducer ONC201 and is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 also has broad-spectrum anti-tumor activity. ONC206 (Oncoceutics) is an imipiridone with nanomolar potency and analogue of ONC201, a selective dopamine receptor D2 (DRD2) antagonist currently being investigated in phase II clinical trials for serous endometrial cancer (SEC).??
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Tiospirone
Tiospirone (BMY 13859-1 free base) is a 5-HT2 receptor antagonist and dopamine blocker that inhibits D2, 5-HT1a, 5-HT7, and sigma receptors.
