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MF-438
CAS No. 921605-87-0
MF-438( —— )
Catalog No. M22502 CAS No. 921605-87-0
MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 236 | In Stock |
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| 2MG | 140 | In Stock |
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| 5MG | 215 | In Stock |
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| 10MG | 328 | In Stock |
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| 25MG | 557 | In Stock |
|
| 50MG | 779 | In Stock |
|
| 100MG | 1079 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2158 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMF-438
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NoteResearch use only, not for human use.
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Brief DescriptionMF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
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DescriptionMF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
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In Vitro——
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In VivoMF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorSCD
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Research Area——
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Indication——
Chemical Information
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CAS Number921605-87-0
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Formula Weight421.44
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Molecular FormulaC19H18F3N5OS
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL (148.30 mM; Need ultrasonic)
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SMILESCc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.
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