Esculetin( Asculetine | CCRIS 7065 | CCRIS-7065 | CCRIS7065 )

Catalog No. M18396 CAS No. 305-01-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Esculetin
Note

Research use only, not for human use.
Brief Description

Esculetin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Esculetin can be found in a number of food items such as dandelion, highbush blueberry, wild leek, and opium poppy.
Description

Esculetin is a β-catenin inhibitor found in chicory and other plant sources. It displays a wide variety of activities, including inhibiting MPTP-induced neurotoxicity and neuronal apoptosis, decreasing body weight, triglyceride levels, total cholesterol and glucose levels in high-fat diet-fed animals, and suppressing proliferation of colon cancer cells.
In Vitro

Western Blot Analysis Cell Line:PANC-1 cells Concentration:100 μM Incubation Time:0-12 h Result:Increased the amount of phosphorylated form of Nrf2.Increased the levels of Nrf2 in nuclear.Decreased NF-κB protein levels.
In Vivo

Animal Model:Imiquimod (HY-B0180) (IMQ)-induced psoriatic mice Dosage:50 and 100 mg/kg/day Administration: p.o., 7d Result:Ameliorated the skin lesion and reduced the PASI score.Inhibited epidermal hyperplasia, and CD8 expression in the skin of psoriatic mice.
Synonyms

Asculetine | CCRIS 7065 | CCRIS-7065 | CCRIS7065
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Others
Research Area

Cancer
Indication

——

1. Cho JH, et al. Int J Oncol. 2015 Jan;46(1):265-71.

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