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Gambogic Acid
CAS No. 2752-65-0
Gambogic Acid( B-Guttiferrin | Beta-Guttiferrin | Beta-Guttilactone )
Catalog No. M17464 CAS No. 2752-65-0
Gambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 104 | In Stock |
|
| 50MG | 148 | In Stock |
|
| 100MG | 219 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGambogic Acid
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NoteResearch use only, not for human use.
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Brief DescriptionGambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1.
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DescriptionGambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. This natural chemical has shown promising antitumor activity in clinical trials. Gambogic acid inhibits cell proliferation, angiogenesis and metastasis. Gambogic acid is currently in clinical trials in China.
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In Vitro——
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In Vivo——
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SynonymsB-Guttiferrin | Beta-Guttiferrin | Beta-Guttilactone
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorBfl-1| Mcl-1| Bcl-2| Bcl-B| Bcl-w
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2752-65-0
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Formula Weight628.75
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Molecular FormulaC38H44O8
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 159.05 mM; H2O : < 0.1 mg/mL
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SMILES[C@]123C4(OC(C2C[C@@H](C=C1C(=O)c1c(O3)c(c2c(c1O)C=CC(O2)(CCC=C(C)C)C)CC=C(C)C)C4=O)(C)C)C/C=C(/C(=O)O)\C
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Chemical Name(Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-2,3a,4,5,7,11-hexahydro-1H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a-yl)-2-methylbut-2-enoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhai D, et al. Mol Y Ther, 2008, 7(6), 1639-1646.
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