MK-212( MK 212 | MK212 )

Catalog No. M15329 CAS No. 61655-58-1

A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.

Purity : >98% (HPLC)

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Biological Information

Product Name

MK-212
Note

Research use only, not for human use.
Brief Description

A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
Description

A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A; stimulates phosphoinositide hydrolysis in cerebral cortex, antagonizes the analgesia induced by either morphine or THIP in vivo.
In Vitro

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In Vivo

——
Synonyms

MK 212 | MK212
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

61655-58-1
Formula Weight

235.12
Molecular Formula

C8H11ClN4.HCl
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 10 mg/mL (42.53 mM)
SMILES

ClC1=CN=CC(N2CCNCC2)=N1.[H]Cl
Chemical Name

6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Conn PJ, et al. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7. 2. Hemrick-Luecke SK, et al. Eur J Pharmacol. 1996 Sep 12;311(2-3):207-11. 3. Jensen AA, et al. J Med Chem. 2013 Feb 14;56(3):1211-27. 4. Murray TF, et al. Eur J Pharmacol. 1983 Jun 3;90(2-3):179-84.

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