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Home - Products - Chromatin/Epigenetic - HAT - SPV 106

SPV 106

CAS No. 1036939-38-4

SPV 106( Pentadecylidenemalonate 1b )

Catalog No. M10183 CAS No. 1036939-38-4

SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SPV 106
  • Note
    Research use only, not for human use.
  • Brief Description
    SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs).
  • Description
    SPV 106 is the first mixed activator/inhibitor of Histone acetyltransferases (HATs), potentiates p300/CBP-associated factor (PCAF) HAT activity while inhibiting those of p300/CBP and recombinant CBP; significantly increases the H3 acetylation level in U937 cells, but no detectable effect on the acetylation level of the non-histone substrate a-tubulin; restores normal levels of H3K9Ac and H3K14Ac, reduces DNA CpG hypermethylation, and recovers D-CMSC proliferation and differentiation, enhances memory for fear extinction and prevents fear renewal in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pentadecylidenemalonate 1b
  • Pathway
    Chromatin/Epigenetic
  • Target
    HAT
  • Recptor
    HAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1036939-38-4
  • Formula Weight
    310.435
  • Molecular Formula
    C18H30O42
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C([O-])/C(C([O-])=O)=C/CCCCCCCCCCCCCC
  • Chemical Name
    Pentadecylidenemalonate 1b

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sbardella G, et al. Bioorg Med Chem Lett. 2008 May 1;18(9):2788-92. 2. Wei W, et al. J Neurosci. 2012 Aug 29;32(35):11930-41. 3. Vecellio M, et al. Diabetes. 2014 Jun;63(6):2132-47. 4. Castellano S, et al. ChemMedChem. 2015 Jan;10(1):144-57.
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