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LY3405105
CAS No. 2326428-25-3
LY3405105( —— )
Catalog No. M24064 CAS No. 2326428-25-3
1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 57 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 146 | In Stock |
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| 25MG | 286 | In Stock |
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| 50MG | 428 | In Stock |
|
| 100MG | 610 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY3405105
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NoteResearch use only, not for human use.
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Brief Description1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.
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Description1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester is a novel CDK7 inhibitors.
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In VitroCDK7-IN-4 (compound I) exhibits significant inhibitory activity against NCI-H446, SNU-16, HCC1806, A2780, MCF7, HCT116, and NCI-H460 cells, with IC50 values of 0.01419, 0,02312, 0.02553, 0.02651, 0.03201, 0.04601, and 0.0479, respectively.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK7
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Research Area——
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Indication——
Chemical Information
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CAS Number2326428-25-3
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Formula Weight497.64
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Molecular FormulaC26H39N7O3
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESO=C(N1CCC(NC2=CC(C)=NC3=C(C(C)C)C=NN23)CC1)OC4CN(C(/C=C/CN(C)C)=O)CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.David Andrew Coates, Carlos montero, bhavin Kumar Rameschandra Patel, et al. Compounds useful for inhibiting cdk7. US 20190144456A1.
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