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Home - Products - Metabolic Enzyme/Protease - Phosphatase - KLH45

KLH45

CAS No. 1632236-44-2

KLH45( —— )

Catalog No. M33995 CAS No. 1632236-44-2

KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KLH45
  • Note
    Research use only, not for human use.
  • Brief Description
    KLH45 is an effective and selective inhibitor of Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2(IC50 = 1.3 nM).
  • Description
    KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.
  • In Vitro
    KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.Cell Viability Assay Cell Line:COS-7 cells.Concentration:2 μM.Incubation Time:16 h.Result:Selectively blocked DDHD2 activity.
  • In Vivo
    KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2?/? mice.Animal Model:Mice.Dosage:5-40 mg/kg.Administration:IP, once.Result:Did not show altered brain TAGs.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1632236-44-2
  • Formula Weight
    458.48
  • Molecular Formula
    C24H25F3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (218.11 mM; Ultrasonic )
  • SMILES
    FC(F)(F)Oc1ccc(cc1)-c1cnn(n1)C(=O)N(CCc1ccccc1)C1CCCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jordon M Inloes, et al. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14924-9.?
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