KHS-101

Research use only, not for human use.

KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype.

KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM); works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo.

RT-PCRCell Line:Rat NPCs Concentration:0.6, 1.7 and 5 μM Incubation Time:24 h Result:Showed a dose-dependent induction of Cdkn1 mRNA expression.Cell Proliferation Assay Cell Line:Rat NPCs Concentration:5 μM Incubation Time:24, 48 and 72 h Result:The vast majority of NPCs stop proliferating within 72 h, become mitotically inactive.

Animal Model:Adult Fisher 344 rats (～10 wk old) Dosage:6 mg/kg Administration:SC, BID for 14 days Result:Increased neuronal differentiation. Reduced proliferation of NPCs.

KHS101

Angiogenesis

HIF/HIF Prolyl-hydroxylase

TACC3

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1262770-73-9

339.46

C18H21N5S

>98% (HPLC)

DMSO: 15 mg/mL; Ethanol: 15 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3

N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine

(-20℃)

With Ice Pack

≥ 2 years