JNJ-42041935( JNJ42041935 )

Catalog No. M10673 CAS No. 1193383-09-3

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HNMR

HPLC

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Product Name

JNJ-42041935
Note

Research use only, not for human use.
Brief Description

JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD.
Description

JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively; shows highly selectivity for PHD relative to FIH (pIC50=4.0); JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB; reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.
In Vitro

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In Vivo

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Synonyms

JNJ42041935
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

PHD1|PHD2|PHD3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1193383-09-3
Formula Weight

346.6493
Molecular Formula

C12H6ClF3N4O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 36 mg/mL
SMILES

ClC1=CC2=C(NC(N3C=C(C(O)=O)C=N3)=N2)C=C1OC(F)(F)F
Chemical Name

1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-

1. Barrett TD, et al. Mol Pharmacol. 2011 Jun;79(6):910-20.

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