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JC124

CAS No. 1638611-48-9

JC124( —— )

Catalog No. M34086 CAS No. 1638611-48-9

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    JC124
  • Note
    Research use only, not for human use.
  • Brief Description
    JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
  • Description
    JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.
  • In Vitro
    JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro.
  • In Vivo
    JC124 (100?mg/kg; i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1.Animal Model:Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI) Dosage:100?mg/kg Administration:i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI Result:Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.
  • Synonyms
    ——
  • Pathway
    NF-κB
  • Target
    NOD
  • Recptor
    NOD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1638611-48-9
  • Formula Weight
    382.86
  • Molecular Formula
    C17H19ClN2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (652.98 mM; Ultrasonic; (HCL ，pH≈3); )
  • SMILES
    CNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ram Kuwar, et al. A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury. J Neuroinflammation. 2019 Apr 11;16(1):81.?
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