Isotretinoin

Research use only, not for human use.

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne.

Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain Y, pancreatic Y and more.

Cell Viability Assay Cell Line:HepG2 Concentration:0.1, 0.5, 1, 5, 10, 20, and 40 μM Incubation Time:24, 48, 72, and 96 h Result:Showed a significant reduction in cell viability (less than 30%) at 96 h for all doses.RT-PCR Cell Line:HepG2 Concentration:10 μM Incubation Time:48 hResult:Significantly reduced the expression of c-MYC mRNA by ~80%.

Animal Model:Male A/J mice, lung carcinogenesis modelDosage:1.3, 20.7, or 481 μg/LAdministration:Inhalation exposure, 45 min daily for 2 weeksResult:Reduced the tumor multiplicity. Caused up-regulation of lung tissue nuclear retinoic acid receptors (RARs) relative to vehicle-exposed mice, RARα (3.9-fold vehicle), RARβ (3.3-fold), and RARγ (3.7-fold) at 20.7 μg/L.Animal Model:Wistar rats, tooth extraction model.Dosage:7.5 mg/kg.Administration:Oral gavage, daily for 30 daysResult:Accelerated the process of alveolar repair, significantly decreased serum calcium levels.

AGN 190013 | 13(Z)-Retinoic Acid | 13-cis-Vitamin A Acid

Metabolic Enzyme/Protease

Retinoid Receptor

RAR

Cancer

——

4759-48-2

300.44

C20H28O2

>98% (HPLC)

Ethanol: 1 mg/mL warmed (3.32 mM); DMSO: 60 mg/mL (199.7 mM)

CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C/C(O)=O

(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

(-20℃)

With Ice Pack

≥ 2 years