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IL-4-inhibitor-1

CAS No. 1332184-63-0

IL-4-inhibitor-1( —— )

Catalog No. M34855 CAS No. 1332184-63-0

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

IL-4-inhibitor-1
Note

Research use only, not for human use.
Brief Description

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM).
Description

IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM.
In Vitro

IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context.IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 μM, but did not affect the levels of STAT-6.
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

IL Receptor
Recptor

IL Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1332184-63-0
Formula Weight

321.31
Molecular Formula

C18H12FN3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (311.23 mM; Ultrasonic )
SMILES

Nc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654.?

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