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IDN-7314
CAS No. 254750-11-3
IDN-7314( IDN7314 | IDN 7314 )
Catalog No. M13762 CAS No. 254750-11-3
A potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIDN-7314
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8.
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DescriptionA potent, orally active, and irreversible pan-Caspase protease inhibitor with IC50 of <0.08 to 7 nM for inhibition of activated caspase 3, 6 and 8; also potently inhibited Fas-induced apoptosis of Jurkat cells with IC50 of 6.3 nM, demonstrates protective activity in the mouse model of Fas-induced hepatitis (ED50=0.7mg/kg, p.o.); synergistically inhibits tumor growth by activation of necroptosis and increased secretion of TNFα in a model of colon carcinoma combined with 5-FU.
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In Vitro——
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In Vivo——
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SynonymsIDN7314 | IDN 7314
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase
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Research Area——
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Indication——
Chemical Information
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CAS Number254750-11-3
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Formula Weight549.382
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Molecular FormulaC22H17F6N3O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=C(C=CC=C2F)F
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Chemical Name(S)-3-((S)-2-(2-((2,6-difluorophenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Oliver Metzig M, et al. Oncogene. 2016 Jun 30;35(26):3399-409.
2. Ueno H, et al. Bioorg Med Chem Lett. 2009 Jan 1;19(1):199-202.
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