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HQ461

CAS No. 1226443-41-9

HQ461( —— )

Catalog No. M28932 CAS No. 1226443-41-9

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HQ461
  • Note
    Research use only, not for human use.
  • Brief Description
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
  • Description
    HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
  • In Vitro
    Western Blot Analysis Cell Line:A549 cells Concentration:10 μM Incubation Time:0-8h Result:Induces 50% reduction of CDK12 protein level at 8 h, and>8 fold reduction of the CCNK protein level at 4 h.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1226443-41-9
  • Formula Weight
    345.44
  • Molecular Formula
    C15H15N5OS2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (180.93 mM)
  • SMILES
    Cc1cnc(NC(=O)Cc2csc(Nc3cccc(C)n3)n2)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25(1):81-92.
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