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HIF2α-IN-1
CAS No. 1799948-06-3
HIF2α-IN-1( HIF-2alpha IN-1 | HIF 2alpha-IN-1 | HIF-2alpha-IN-1 )
Catalog No. M12731 CAS No. 1799948-06-3
A potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 357 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2790 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameHIF2α-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay.
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DescriptionA potent HIF-2α inhibitor with IC50 of <500 nM in HIF-2α scintillation proximity assay.
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In Vitro——
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In Vivo——
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SynonymsHIF-2alpha IN-1 | HIF 2alpha-IN-1 | HIF-2alpha-IN-1
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PathwayAngiogenesis
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TargetHIF/HIF Prolyl-hydroxylase
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RecptorHIF/HIF Prolyl-hydroxylase
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number1799948-06-3
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Formula Weight405.2961
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Molecular FormulaC16H8F5NO4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESN#CC1=CC(F)=CC(OC2=CC=C3C([C@@H](O)C(F)(F)S3(=O)=O)=C2C(F)F)=C1
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Chemical NameBenzonitrile, 3-[[(3R)-4-(difluoromethyl)-2,2-difluoro-2,3-dihydro-3-hydroxy-1,1-dioxidobenzo[b]thien-5-yl]oxy]-5-fluoro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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OHM1
OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM.
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TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
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Naphthofluorescein
Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects.
