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Flumatinib
CAS No. 895519-90-1
Flumatinib( HHGV678 )
Catalog No. M19237 CAS No. 895519-90-1
Flumatinib is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | In Stock |
|
| 10MG | 71 | In Stock |
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| 25MG | 116 | In Stock |
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| 50MG | 149 | In Stock |
|
| 100MG | 258 | In Stock |
|
| 200MG | 387 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFlumatinib
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NoteResearch use only, not for human use.
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Brief DescriptionFlumatinib is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.
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DescriptionFlumatinib is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.(In Vitro):Flumatinib (HH-GV-678) can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell. In higher concentration, Flumatinib can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell, however, Flumatinib has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src and HER2 . Flumatinib (HHGV678) effectively overcame the drug resistance of certain KIT mutants with activation loop mutations (i.e., D820G, N822K, Y823D, and A829P) .
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In VitroFlumatinib (HH-GV-678) can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell. In higher concentration, Flumatinib can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell, however, Flumatinib has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src and HER2 . Flumatinib (HHGV678) effectively overcame the drug resistance of certain KIT mutants with activation loop mutations (i.e., D820G, N822K, Y823D, and A829P) .
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In Vivo——
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SynonymsHHGV678
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PathwayGPCR/G Protein
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TargetcAMP
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Recptorc-Abl|PDGFRβ|c-Kit|
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number895519-90-1
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Formula Weight562.6
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Molecular FormulaC29H29F3N8O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 32 mg/mL; 56.88 mM
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SMILESCC1=C(C=C(C=N1)NC(=O)C2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9.
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