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Famciclovir

CAS No. 104227-87-4

Famciclovir( BRL-42810 )

Catalog No. M10213 CAS No. 104227-87-4

A guanine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 27 In Stock
50MG 39 In Stock
100MG 65 In Stock
200MG 85 In Stock
500MG 189 In Stock
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Biological Information

  • Product Name
    Famciclovir
  • Note
    Research use only, not for human use.
  • Brief Description
    A guanine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections.
  • Description
    A guanine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections. HSV Infection Approved(In Vitro):Famciclovir metabolizes into BRL 42359 by deacetylation and then oxidizes to penciclovir.(In Vivo):Famciclovir (50-400 mg/kg; p.o. three times per day for total 10 doses) effectively cures necrotic hepatitis mice.
  • In Vitro
    Famciclovir metabolizes into BRL 42359 by deacetylation and then oxidizes to penciclovir.
  • In Vivo
    Famciclovir (50-400 mg/kg; p.o. three times per day for total 10 doses) effectively cures necrotic hepatitis mice. Animal Model:Four- to five-week-old Balb/c mice with HSV-1 infection Dosage:50, 100, 200 and 400 mg/kg Administration:Oral gavage; 50-400 mg/kg per day divided into three doses given every 8 h; for total 10 doses Result:Significantly reduced the incidence of hepatitis with a dose of 50 mg/kg per day, and could not isolated infectious virus from the doses of 50 and 100 mg/kg treatment group.
  • Synonyms
    BRL-42810
  • Pathway
    Microbiology/Virology
  • Target
    HSV
  • Recptor
    DNApolymerase|HSV
  • Research Area
    Infection
  • Indication
    HSV Infection

Chemical Information

  • CAS Number
    104227-87-4
  • Formula Weight
    321.3318
  • Molecular Formula
    C14H19N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(OCC(COC(C)=O)CCN1C=NC2=CN=C(N)N=C12)=O
  • Chemical Name
    1,3-Propanediol, 2-[2-(2-amino-9H-purin-9-yl)ethyl]-, 1,3-diacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Vere Hodge RA, et al. Antimicrob Agents Chemother. 1989 Oct;33(10):1765-73. 2. Harnden MR, et al. J Med Chem. 1989 Aug;32(8):1738-43. 3. Tsiquaye KN, et al. J Med Virol. 1994 Mar;42(3):306-10.
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