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Enpp-1-IN-14
CAS No. 2687222-59-7
Enpp-1-IN-14( —— )
Catalog No. M28549 CAS No. 2687222-59-7
ENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 410 | Get Quote |
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| 50MG | 605 | Get Quote |
|
| 100MG | 860 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEnpp-1-IN-14
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NoteResearch use only, not for human use.
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Brief DescriptionENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.
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DescriptionENPP1-IN-2 is a potent inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.(In Vivo):ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth in Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells).
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In Vitro——
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In VivoEnpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth. Animal Model:Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)Dosage:50 mg/kg Administration:IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)Result:Significantly inhibited tumor growth.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorKSP
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Research Area——
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Indication——
Chemical Information
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CAS Number2687222-59-7
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Formula Weight403.88
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Molecular FormulaC15H22ClN5O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 9.62 mg/mL (23.82 mM)
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SMILESCl.O=S(=O)(N)N1CCN(C=2N=CN=C3C=C(OC)C(OC)=CC32)CCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Woessner R, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009 Nov;29(11):4373-80.
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