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Emricasan

CAS No. 254750-02-2

Emricasan( IDN-6556 | PF-03491390 )

Catalog No. M13761 CAS No. 254750-02-2

Emricasan (IDN-6556;PF-03491390) is a potent, irreversible pan-caspase inhibitor, shows neuroprotective activity for hNPCs, inhibits ZIKV-induced increased caspase-3 activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Emricasan
  • Note
    Research use only, not for human use.
  • Brief Description
    Emricasan (IDN-6556;PF-03491390) is a potent, irreversible pan-caspase inhibitor, shows neuroprotective activity for hNPCs, inhibits ZIKV-induced increased caspase-3 activity.
  • Description
    Emricasan (IDN-6556;PF-03491390) is a potent, irreversible pan-caspase inhibitor, shows neuroprotective activity for hNPCs, inhibits ZIKV-induced increased caspase-3 activity.Steatohepatitis Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    IDN-6556 | PF-03491390
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    Caspase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    254750-02-2
  • Formula Weight
    569.51
  • Molecular Formula
    C26H27F4N3O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 93 mg/mL (163.3 mM); Ethanol: 93 mg/mL (163.3 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(O)C[C@H](NC([C@H](C)NC(C(NC1=CC=CC=C1C(C)(C)C)=O)=O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O
  • Chemical Name
    (3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xu M, et al. Nat Med. 2016 Oct;22(10):1101-1107. 2. Brumatti G, et al. Sci Transl Med. 2016 May 18;8(339):339ra69. 3. McCall MD, et al. Transplantation. 2012 Jul 15;94(1):30-5.
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