Edecesertib( —— )

Catalog No. M35644 CAS No. 2408839-73-4

Edecesertib (GS-5718) is a selective, orally active IRAK-4 inhibitor with anti-inflammatory properties, applicable for the study of rheumatoid arthritis (RA) and lupus erythematosus (LE).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Edecesertib
Note

Research use only, not for human use.
Brief Description

Edecesertib (GS-5718) is a selective, orally active IRAK-4 inhibitor with anti-inflammatory properties, applicable for the study of rheumatoid arthritis (RA) and lupus erythematosus (LE).
Description

Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) research.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Immunology/Inflammation
Target

IRAK
Recptor

IRAK
Research Area

——
Indication

——

Chemical Information

CAS Number

2408839-73-4
Formula Weight

435.45
Molecular Formula

C22H22FN7O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (229.65 mM; Ultrasonic )
SMILES

N([C@@H](C#N)C)C=1C=C(C=2N3C(=CC2)C=C(C#N)C=N3)N=CC1C(NC[C@H](C(C)(C)O)F)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Roedder S, et, al. Phase 1 Study Results of GS-5718, an Oral IRAK4-Inhibitor: Pharmacodynamics of Single and Multiple Doses of GS-5718 in Healthy Subjects. 2021 Nov 6.

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